1. 细胞的基础信息

2. 细胞常见的研究有哪些？

a) 研究人胃癌细胞的生物学特性

b) 药物筛选及癌症治疗的研发

c) 构建人胃癌细胞类器官模型

d) 有关人胃癌细胞发病机制的研究

3. 细胞相关的文献有哪些？

师文,韩炜,孙焕焕,等.CHST11基因对胃癌SGC-7901细胞生物学行为的影响[J].中国细胞生物学学报,2023,45(07):1020-1028.

（目的：探究CHST11基因对胃癌SGC-7901细胞生物学行为的影响。方法：应用q RT-PCR技术检测CHST11 m RNA在胃癌SGC-7901细胞中的表达情况。细胞转染干扰CHST11的sh-CHST11质粒和对照NC质粒,应用q RT-PCR及Western blot法分别检测CHST11基因稳定沉默后胃癌细胞CHST11 mRNA和蛋白的表达情况,应用转染后的细胞进行后续研究;采用MTT方法及平板克隆实验,分别观察CHST11基因稳定沉默对胃癌细胞增殖及克隆形成的影响;应用流式细胞技术检测转染后胃癌细胞的凋亡情况;通过划痕、Transwell实验,观察CHST11基因稳定沉默对胃癌细胞迁移、侵袭能力的影响。结果：CHST11基因在胃癌细胞中的表达上调;稳定沉默后的胃癌细胞SGC-7901-sh-CHST11的增殖、迁移及侵袭能力均显著低于未经干预的SGC-7901, SGC-7901-sh-CHST11细胞凋亡数明显增多;且SGC-7901-NC细胞的增殖、迁移、侵袭及凋亡情况与未经干预的SGC-7901相比均无显著差异。结论：CHST11可促进胃癌细胞的增殖、迁移及侵袭,抑制凋亡,对胃癌的发生发展有促进作用。）

[1] Zhang X, Qin Y, Pan Z, Li M, Liu X, Chen X, Qu G, Zhou L, Xu M, Zheng Q, Li D. Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302.

（The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present study examined the in vitro effects of CBD on human gastric cancer SGC-7901 cells. We found that CBD significantly inhibited the proliferation and colony formation of SGC-7901 cells. Further investigation showed that CBD significantly upregulated ataxia telangiectasia-mutated gene (ATM) and p53 protein expression and downregulated p21 protein expression in SGC-7901 cells, which subsequently inhibited the levels of CDK2 and cyclin E, thereby resulting in cell cycle arrest at the G0–G1 phase. In addition, CBD significantly increased Bax expression levels, decreased Bcl-2 expression levels and mitochondrial membrane potential, and then upregulated the levels of cleaved caspase-3 and cleaved caspase-9, thereby inducing apoptosis in SGC-7901 cells. Finally, we found that intracellular reactive oxygen species (ROS) increased after CBD treatment. These results indicated that CBD could induce G0–G1 phase cell cycle arrest and apoptosis by increasing ROS production, leading to the inhibition of SGC-7901 cell proliferation, thereby suggesting that CBD may have therapeutic effects on gastric cancer.）